CoQ10 may help support a healthy balance of LDL (low-density lipoprotein) cholesterol, particularly in individuals with metabolic concerns or those taking statins. While not a licensed cholesterol-lowering treatment, research has shown that CoQ10 contributes to the protection of cells from oxidative stress and supports normal energy production in the body. These functions are especially important for cardiovascular health. Some studies also report modest improvements in lipid profiles when CoQ10 is used alongside other lifestyle or medical interventions.
What Is CoQ10?
Coenzyme Q10 (CoQ10) is a compound naturally produced in the body, found in every cell, and vital for energy production in mitochondria. It also functions as an antioxidant, protecting cells, especially in the heart and blood vessels, from oxidative damage. CoQ10 exists in two forms: ubiquinone (the oxidised form) and ubiquinol (the active antioxidant form).
How Might CoQ10 Affect LDL Cholesterol?
CoQ10 is best known for its role in supporting energy production and protecting cells from oxidative stress, functions that are especially important in organs like the heart. As a result, it’s often explored in research for its potential role in cardiovascular health, particularly in people over 40 or those taking statins.
One 2022 meta-analysis of randomised controlled trials found that CoQ10 supplementation reduced LDL cholesterol levels in individuals with metabolic diseases by an average of 3 mg/dL [1]. The study concluded that CoQ10 could offer modest lipid-lowering effects alongside other interventions.
However, this effect is not as robust or consistent as that of statins. More research is needed here. Instead, CoQ10’s main strength lies in its ability to improve endothelial function and reduce oxidative stress, which are both crucial for heart health.
CoQ10 and Statins: Supporting Heart Health
Statin medications, which lower cholesterol, are known to reduce natural levels of CoQ10 in the body, often leading to muscle pain, fatigue, or weakness in some individuals. Supplementing with CoQ10 has been shown to reduce these side effects and restore mitochondrial function.
A 2021 review highlighted that CoQ10 supplementation improved endothelial function and reduced oxidative markers in patients with cardiovascular disease [2]. Another 2020 meta analysis reported that CoQ10 reduced statin-associated muscle symptoms (SAMS) significantly compared to placebo [3].
Other Heart Health Benefits of CoQ10
- Improves energy production in heart muscle cells
- Reduces oxidative stress and inflammation in blood vessels
- May lower blood pressure slightly in people with hypertension [4]
- Improves exercise tolerance in patients with heart failure [5]
These benefits make CoQ10 a valuable option for those looking to support cardiovascular health, particularly when combined with other healthy lifestyle choices and, where appropriate, medication.
Who Might Want to Consider Supplementing CoQ10
CoQ10 may be worth considering for anyone looking to support their heart health, particularly adults over 40, as natural levels of CoQ10 decline with age.
It’s especially relevant for people taking statin medications, which are known to deplete CoQ10 in the body and can lead to muscle aches or fatigue. Those with high cholesterol, high blood pressure, or a family history of cardiovascular disease may also benefit from the antioxidant and energy-supporting properties of CoQ10. However, those who have existing medical conditions or are taking medications should always consult with their GP or a herbalist before adding any new supplements into their routine.
Additionally, if you experience low energy levels or fatigue, CoQ10 supplementation may help support mitochondrial function and overall vitality.
What to Look for in a CoQ10 Supplement
When choosing a CoQ10 supplement, look for the ubiquinol form, the active, antioxidant form of CoQ10 that is better absorbed by the body, especially as we age. More on the differences here.
Since CoQ10 is fat-soluble, it’s best taken with food containing fat to aid absorption. Avoid products with unnecessary fillers or artificial additives.
If you're looking to supplement, Napiers Japanese Energy CoQ10, provides Kaneka ubiquinol, the active and bioavailable form of CoQ10. Kaneka is one of the worlds most researched ubiquinol supplements.
How to Take CoQ10
- Form: Ubiquinol is better absorbed than ubiquinone, especially in older adults.
- Dose: Typically 100–300mg daily, with higher doses often recommended for those on statins.
- With food: Always take CoQ10 with a fat-containing meal to enhance absorption.
CoQ10 isn’t a substitute for cholesterol-lowering medication, but research suggests it may modestly reduce LDL levels in some people and, more importantly, provide strong support for overall cardiovascular health.
FAQs: CoQ10 and Cholesterol
Does CoQ10 directly lower LDL cholesterol?
Some studies suggest a modest reduction in LDL cholesterol with CoQ10, especially in people with metabolic conditions, but the primary benefits are antioxidant and cardiovascular support. However, more research is needed here.
Should I take CoQ10 if I’m on statins?
Yes, many healthcare providers recommend CoQ10 alongside statins to reduce muscle-related side effects and replenish depleted CoQ10 levels.
Is CoQ10 better than red yeast rice or plant sterols for cholesterol?
No, those ingredients have more direct cholesterol-lowering mechanisms. CoQ10 is best used for heart support and statin-related side effects.
How long does CoQ10 take to work?
You may start feeling energy or muscle improvements within 4–8 weeks, with cardiovascular markers taking longer (up to 12 weeks or more).
Is CoQ10 safe to take long-term?
Yes, CoQ10 is generally safe with few side effects. It’s advisable to speak with a healthcare practitioner if you’re taking medication or are pregnant or breastfeeding.
References
- Z Liu , Z Tian , D Zhao , Y Liang , S Dai , M Liu , S Hou , X Dong , Zhaxinima , Y Yang (2022). Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. JCEM
- Y Rabanal-Ruiz, E Llanos-González, F J Alcain (2021). The Use of Coenzyme Q10 in Cardiovascular Diseases. PubMed.
- C Kennedy, Y Köller, E Surkova (2020). Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy. ScienceDirect.
- D Zhao, Y Liang, S Dai, S Hou, Z Liu, M Liu, X Dong, Y Zhan, Z Tian, Y Yang (2022). Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders. PubMed.
- L Le, Y Liu (2017). Efficacy of coenzyme Q10 in patients with cardiac failure. PubMed
This content is for educational purposes only and is not intended to diagnose, treat, or replace medical advice. Always consult a qualified healthcare professional before starting any new supplement, especially if taking medication or managing a health condition.
